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From Wikipedia

Body water

In medicine, body water is all of the water content of the human body. A significant fraction of the human body is water.

Guyton's Textbook of Medical Physiology states that "the total amount of water in a man of average weight (70 kilograms) is approximately 40 liters, averaging 57 percent of his total body weight. In a newborn infant, this may be as high as 75 percent of the body weight, but it progressively decreases from birth to old age, most of the decrease occurring during the first 10 years of life. Also, obesity decreases the percentage of water in the body, sometimes to as low as 45 percent". These figures are statistical averages, so are illustrative, and like all biostatistics, will vary with things like type of population, age and number of people sampled, and methodology. So there is not, and cannot be, a figure that is exactly the same for all people, for this or any other physiological measure. For example, Jackson's (1985) Anatomy & Physiology for Nurses gives a figure of 60% for the proportion of body-weight attributable to water, which approximates Guyton's 57%.

Skin also contains much water. The human body is about 60% water in adult males and 55% in adult females.

In diseased states where body water is affected, the compartment or compartments that have changed can give clues to the nature of the problem. Body water is regulated by hormones, including anti-diuretic hormone (ADH), aldosterone and atrial natriuretic peptide.

There are many methods to determine body water. One way to get a simple estimate is by calculation.

Per Netter's Atlas of Human Physiology, body water is broken down into the following compartments:

  • Intracellular fluid (2/3 of body water). Per Guyton, in a body containing 40 liters of fluid, about 25 liters is intracellular, which amounts to 62.5% (5/8), close enough to the 2/3 rule of thumb. Jackson's texts states 70% of body fluid is intracellular.
  • Extracellular fluid (1/3 of body water). Per Guyton's illustration, for a 40 litre body, about 15 litres is extracellular, which amounts to 37.5% Again, this is close to the 1/3 rule of thumb cited here.
    • Plasma (1/5 of extracellular fluid). Per Guyton's illustration, of the 15 litres of extracellular fluid, plasma volume averages 3 litres. This amounts to 20%, the same as per Netter's Atlas.
    • Interstitial fluid (4/5 of extracellular fluid)
    • Transcellular fluid (a.k.a. "third space," normally ignored in calculations)

Measurement of body water

Dilution and equilibration

Total body water can be determined using Flowing afterglow mass spectrometry [http://www.fa-ms.com FA-MS] measurement of deuterium abundance in breath samples from individuals. A known dose of deuterated water (Heavy water, D2O) is ingested and allowed to equilibrate within the body water. The FA-MS instrument then measures the deuterium-to-hydrogen (D:H) ratio in the exhaled breath water vapour. The total body water is then accurately measured from the increase in breath deuterium content in relation to the volume of D2O ingested.

Different substances can be used to measure different fluid compartments:

Intracellular fluid may then be estimated by subtracting extracellular fluid from total body water.

Bioelectrical impedance analysis

Another method of determining total body water percentage (TBW%) is via Bioelectrical Impedance Analysis (BIA). In the traditional BIA method, a person lies on a cot and spot electrodes are placed on the hands and bare feet. Electrolyte gel is applied first, and then a current of 50 kHz is introduced. BIA has emerged as a promising technique because of its simplicity, low cost, high reproducibility and noninvasiveness. BIA prediction equations can be either generalized or population-specific, allowing this method to be potentially very accurate. Selecting the appropriate equation is important to determining the quality of the results.

For clinical purposes, scientists are developing a multi-frequency BIA method that may further improve the method's ability to predict a person's hydration level. New segmental BIA equipment that uses more electrodes may lead to more precise measurements of specific parts of the body.

Fluid loss

Volume contraction is a decrease in body fluid volume, with or without a concomitant loss of osmolytes. The loss of the body water component of body fluid is specifically termed dehydration.

Na+ loss approximately correlates with fluid loss from extracellular fluid (ECF), since Na+ has a much higher concentration in ECF than intracellular fluid (ICF). In contrast, K+ has a much higher concentration in ICF than ECF, and therefore its loss rather correlates with fluid loss from ICF, since K+ loss from ECF causes the K+ in ICF to diffuse out of the cells, dragging water with it by osmosis.

From Encyclopedia


osmosis , transfer of a liquid solvent through a semipermeable membrane that does not allow dissolved solids (solutes) to pass. Osmosis refers only to transfer of solvent; transfer of solute is called dialysis . In either case the direction of transfer is from the area of higher concentration of the material transferred to the area of lower concentration. This spontaneous migration of a material from a region of higher concentration to a region of lower concentration is called diffusion . Principles of Osmosis Osmosis will occur if a vessel is separated into two compartments by a semipermeable membrane, both compartments are filled to the same level with a solvent, and solute is added to one side. The level of the liquid on the side containing the solute will rise as the solvent flows from the side of its higher concentration to the side of lower concentration. If an external pressure is exerted on the side containing the solute, the transfer of solvent can be stopped and even reversed (reverse osmosis). Two solutions separated by a semipermeable membrane are said to be isotonic if no osmosis occurs. If osmosis occurs, transfer of solvent is from the hypotonic solution to the hypertonic solution, which has the higher osmotic pressure. The minimum pressure necessary to stop solvent transfer is called the osmotic pressure. Since the osmotic pressure is related to the concentration of solute particles, there is a mathematical relationship between osmotic pressure, freezing-point depression, and boiling-point elevation. Properties such as osmotic pressure, freezing point, and boiling point, which depend on the number of particles present rather than on their size or chemical nature, are called colligative properties. For dilute solutions the mathematical relationship between the osmotic pressure, temperature, and concentration of solute is much like the relation between pressure, temperature, and volume in an ideal gas (see gas laws ). A number of theories explaining osmotic pressure by analogy to gases have been devised, but most have been discarded in favor of thermodynamic interpretations using such concepts as the entropy of dilution. Biological Importance of Osmosis Osmosis and dialysis are of prime importance in living organisms, where they influence the distribution of nutrients and the release of metabolic waste products. Living cells of both plants and animals are enclosed by a semipermeable membrane called the cell membrane, which regulates the flow of liquids and of dissolved solids and gases into and out of the cell. The membrane forms a selective barrier between the cell and its environment; not all substances can pass through the membrane with equal facility. Without this selectivity, the substances necessary to the life of the cell would diffuse uniformly into the cell's surroundings, and toxic materials from the surroundings would enter the cell. If blood cells (or other cells) are placed in contact with an isotonic solution, they will neither shrink nor swell. If the solution is hypertonic, the cells will lose water and shrink (plasmolyze). If the solution is hypotonic (or if pure solvent is used) the cells will swell; the osmotic pressure that is developed may even be great enough to rupture the cell membrane. Saltwater from the ocean is hypertonic to the cells of the human body; the drinking of ocean water dehydrates body tissues instead of quenching thirst. In plants osmosis is at least partially responsible for the absorption of soil water by root hairs and for the elevation of the liquid to the leaves of the plant. However, plants wilt when watered with saltwater or treated with too much fertilizer, since the soil around their roots then becomes hypertonic.

From Yahoo Answers

Question:i'm studying for my exam and looked at a past exam paper and i found this question difficult so cud u pls help! question : explain why osmosis and active transport are neccessary, including an example of where each may occur in an organism.

Answers:Ok, I haven't taken biology in two years but here's what I remember: Osmosis is necessary because it helps to maintain an equilibrium in an organism. For example, red blood cells in the human body use diffusion to regulate the amount of water that passes in or out. It keeps the water level balanced. Certain particles cannot pass through some membranes however. Cell membranes have specialized proteins that allow their nutrients to transport into the cell using energy.This process is called active transport. It's necessary because cells need nutrients in order to live and this process allows it to do so against the concentration gradient. Well, that's basically a summary of what happens. Good Luck!

Question:Note, these are several questions in my hw. I don't get them. I added the explain part because I don't get how to answer it. This is an optional /extra credit/ assignment, thanks in advance. Direct ans *WBC=white blood cells 1) Do all WBCs work like Osmosis Jones to protect our Bodies? Explain. ( background info: In the spotlight in Frank (the city) is Osmosis Jones, a white blood cell, who is over-eager and consequently ends up in sticky situations that make him highly unpopular. He notices a virus, and tries to help fight it. ) 2) What is the mode of transportation for the WBCs in a human body? 3) Before Frank (the city) took the cold pill "Drix," what kind of immunity was his body using to protect itself? Explain. After, what kind of immunity was protecting him? Explain. 4) What would you find in the armpit area to help with the circulatory system besides the fungal cells? 5) When do the # of WBCs in the blood increase? 6) Why do you think temperature rises (you get a fever)

Answers:1. No. The actions of osmosis Jones merely describe the function of 1 or 2 of several different types of leukocytes (WBC). Not all leukocytes are over-eager; some wait for the responses of other leukocytes in other to elicit its function. For example, eosinophils can only kill micro-organisms which have been coated with antibodies. Antibodies are small proteins that bind specifically to certain organisms in order to mark them. This is one of the ways the body tells "the self" from the "non-self", a very important concept in immunology. One other example is the small lymphocyte. Its function is the production of antibodies (B-cells) and cytotoxic and helper functions (T-cells). So you see, for the most part, the immune system is a group effort. Not a one-man-show as Osmosis Joe is trying to come across. 2. The lympatic system consist of a system of valves, ducts, and nodes. It transports lymph fluid, WBC are found here, throughout the body. 3. Before the pill, the body protects itself by mechanisms called innate immunity response. The word "innate" refers to the fact that all these mechanisms are derived entirely from the genes a person inherits from their parents. After the pill, the defense mechanisms employed are called adaptive immune response because it is organized around an ongoing infection and adapts to the nuances of the pathogen. 4. Lymph nodes are found here. Lymph node is the site where lymph fluid is filtered and pathogens are phagocitized and detoxed to protect the body. 5. Leukocytes are increased shortly after an infection is detected. Cells already at the infection site produce cytokines that elicit several functions. One of the functions is to help dilate blood vessels in order to recruit more leukocytes to enter the infection from the blood stream. The overall effect is molecules of the immune system are brought rapidly and in large numbers to the infected tissue. 6. Cytokines brings about this response. Cells and proteins in the damaged tissue sense the presence of pathogens and send out soluble proteins called cytokines that interact with other cells to trigger the immune response. The overall effect is to induce heat, pain (and redness/swelling) at the infected tissue. The benefit of heat are that it inhibits bacterial growth and dilates vessels to recruit more leukocytes. You can think of this as a positive feedback system.

Question:how does diffusion, osmosis, and active transport aid cellular activities and maintain homeostasis?? i really dont get this please help

Answers:OK Diffusion is the process by which two liquids naturally mix together for example if you pour squash into water they will eventually mix completely together even without stirring. Osmosis is essentially the same thing but it must be 'the diffusion of water across a partially permeable membrane'. A partially permeable membrane is essentially like a sieve but much finer it can seperate water from things its dissolved in. Active transport takes place when a substance is absorbed across the concentration gradient, this doesn't happen much in the body, one example is the re-absorption of glucose in the kidneys. These things all help to maintain homeostasis by keeping conditions and concentrations of liquids in cells the same at all times. Hope this helped but i guess you might have wanted a simpler answer sorry this is all i know.

Question:I need Help! Book is called: STRUCTURE AND FUCTION OF THE HUMAN BODY. MY BOOK WAS STOLEN AND I NEED HELP!? i NEED REAL HELP PLEASE MY BOOK HAS BEEN STOLEN. pLEASE NO NEGATIVITY. MY CLASS ENDS SOON. Anybpdy with the book please help. By Memmler CHApTER 17 Questions 1. The wave-like movement of the digestive tract will is called_________. 2.AThe small intestine is connecte to the posterior abdominal wall by_________. 3. the liver can store glucose in the form of_______. 4 THe parotid glands secret_______. 5. A tooth is composed mainly of a hard calcified substance called 11. The teeth break up food into small parts by a process called.....A. Absorbtion, B. Degultition, C. Ingestion, D. Mastication 12. Hydrocholoric acid and pepsinare secreted by the......A. Salivary glands,B. Stomach, C.Pancreas, D. Liver 13.The double layer of peritoneum that extends from the lower border of the stomach and hangs over the intestine is the.......A. Greater omentum, B., Lesser omentum, C. Mesentery, D. Mesocolon 14. The soft, fleshy v-shaped mass of tissue that hangs from the soft palate is the...A.Epiglottis, B.Esophageal hiatus, C.uvula, D.Gingiva 15. The entrance of the trachea is guarded during swallowing by the ........A. uvula, B.Epiglottis, C. Gingiva, D. Bolus CHAPTER 18 1. Building glycogen from glucose is an example of______. 2. The amount of energy needed to maintain life functions while at rest is_____. 3. Reserves of gluscose are strored in liver and muscle as_____ 4. Them ost important area of the brain for temperature regulation is the______. 5. Minerals needed in extremely small amounts are referred to as______> 11. During amino acid catabolism, nitrogen is removed by.....A.Oxidation, B. The glycenic effect, C. Lysis, D. Deamination 12. Which of the following would have the lowest glycenic effect?.....A. Glucose, B. Sucrose, .C. Lactose, D. Starch 13. Alcohol is catabolized by the A. Small intestine, B.Liver, C. Pancreas, D. Spleen 14. Amino acids that cannot be made by metabolism are said to be .......A. Essential B. Nonessential C. Antioxidants, D. Free radicals Chapter 19 1. Each kidney is located in the ____Space. 2. THe renal artery, renal vein, and ureter connect to the kidney at the______. 3. The ureters and urethra open at the part of the bladder called the_______. 4. The amount of dissolved substances in urine is indicated by its______. 5. Substances in the blood that prevent sharp changes in hydrogen ion concentration are called_____. 11. The functional unit of the renal system is the.....A. Renal capsule, B. Kidney, Nephron, D. Juxtaglomerular apparatus 12.Fluid moves out of the glomerulus by...A. Filtraion, B. Diffusion, C. OSmosis, D. Active transport 13. One's ability to delay urination is due to voluntary control of the....A. Trigone, B. Internal urethral sphincter, C. External urethral Spincter, D. Urinary Meatus 14. Body water contest is greatest in..A. Infatnts,B. Children, C. Young adults, D. Elderly Adults 15. Fluid located in the spaces between the cells is called......A. Cytoplasm, B. Plasma, C. Interstitial fluid, D. Lymph

Answers:the thing is....that in the time it took you to typle this you could have searched it on the web...

From Youtube

Osmosis Jones Virus :The song is by Seo Taiji, a talented Korean artist. This track is a remix of the original 'To You'. The album is Ultramania released in 2000. Unfortunately, I lose my CD copy and it is out of print. If you're lucky you can find a used copy online to buy. A tribute to the film Osmosis Jones. Its about a Virus who invades the human body via bird dander. He is the Spanish Flu, the deadliest epidemic ever recorded in human history. After contracting the Spanish Flu you could die a few hours later, hense I had the virus character infect the body very quickly. First time I ever used Flash so be gentle. ;)