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From Wikipedia

Alpha helix

A common motif in the secondary structure of proteins, the alpha helix (α-helix) is a right-handed coiled or spiral conformation, in which every backbone N-H group donates a hydrogen bond to the backbone C=O group of the amino acid four residues earlier (i+4 \rightarrow i hydrogen bonding). This secondary structure is also sometimes called a classic Pauling-Corey-Branson alpha helix (see below). Among types of local structure in proteins, the α-helix is the most regular and the most predictable from sequence, as well as the most prevalent.

Historical development

In the early 1930s, William Astbury showed that there were drastic changes in the X-rayfiber diffraction of moist wool or hair fibers upon significant stretching. The data suggested that the unstretched fibers had a coiled molecular structure with a characteristic repeat of ~5.1|Ã…|nm.

Astbury initially proposed a kinked-chain structure for the fibers. He later joined other researchers (notably the American chemist Maurice Huggins) in proposing that:

  • the unstretched protein molecules formed a helix (which he called the α-form); and
  • the stretching caused the helix to uncoil, forming an extended state (which he called the β-form).

Although incorrect in their details, Astbury's models of these forms were correct in essence and correspond to modern elements of secondary structure, the α-helix and the β-strand (Astbury's nomenclature was kept), which were developed by Linus Pauling, Robert Corey and Herman Branson in 1951 (see below); that paper showed both right- and left-handed helices, although in 1960 the crystal structure of myoglobin showed that the right-handed form is the common one. Hans Neurath was the first to show that Astbury's models could not be correct in detail, because they involved clashes of atoms. It is interesting to note that Neurath's paper and Astbury's data inspired H. S. Taylor, Maurice Huggins and Bragg and collaborators to propose models of keratin that somewhat resemble the modern α-helix.

Two key developments in the modeling of the modern α-helix were (1) the correct bond geometry, thanks to the crystal structure determinations of amino acids and peptides and Pauling's prediction of planarpeptide bonds; and (2) his relinquishing of the assumption of an integral number of residues per turn of the helix. The pivotal moment came in the early spring of 1948, when Pauling caught a cold and went to bed. Being bored, he drew a polypeptide chain of roughly correct dimensions on a strip of paper and folded it into a helix, being careful to maintain the planar peptide bonds. After a few attempts, he produced a model with physically plausible hydrogen bonds. Pauling then worked with Corey and Branson to confirm his model before publication. In 1954 Pauling was awarded his first Nobel Prize "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances"[http://nobelprize.org/nobel_prizes/chemistry/laureates/1954/] (such as proteins), prominently including the structure of the α-helix.

Structure

Geometry and hydrogen bonding

The amino acids in an α helix are arranged in a right-handed helical structure where each amino acid residue corresponds to a 100° turn in the helix (i.e., the helix has 3.6 residues per turn), and a translation of 1.5|Å|nm|abbr=on along the helical axis. (Short pieces of left-handed helix sometimes occur with a large content of achiral glycine amino acids, but are unfavorable for the other normal, biological D-amino acids.) The pitch of the alpha-helix (the vertical distance between two consecutive turns of the helix) is 5.4|Å|nm|abbr=on which is the product of 1.5 and 3.6. What is most important is that the N-H group of an amino acid forms a hydrogen bond with the C=O group of the amino acid four residues earlier; this repeated i+4 \rightarrow i hydrogen bonding is the most prominent characteristic of an α-helix. Official international nomenclature [http://www.chem.qmul.ac.uk/iupac/misc/ppep1.html] specifies two ways of defining α-helices, rule 6.2 in terms of repeating φ,ψ torsion angles (see below) and rule 6.3 in terms of the combined pattern of pitch and hydrogen bonding. The alpha-helices can be identified in protein structure using several computational methods, one of which is DSSP (Dictionary of Protein Secondary Structure).

Similar structures include the 310 helix (i+3 \rightarrow i hydrogen bonding) and the π-helix (i+5 \rightarrow i hydrogen bonding). The α helix can be described as a 3.613 helix, since the i + 4 spacing adds 3 more atoms to the H-bonded loop compared to the tighter 310 helix. The subscripts refer to the number of atoms (including the hydrogen) in the closed loop formed by the hydrogen bond.

Residues in α-helices typically adopt backbone (φ, ψ) dihedral angles around (-60°, -45°), as shown in the image at right. In more general terms, they adopt dihedral angles such that the ψ dihedral angle of one residue and the φ dihedral angle of the next residue sum to roughly -105°. As a consequence, α-helical dihedral angles, in general, fall on a diagonal stripe on the Ramachandran diagram (of slope -1), ranging from (-90°, -15Â


From Yahoo Answers

Question:How many times greater is the distance from Earth to Alpha Centauri (4.4 light-years) than the distance from Earth to the Moon? Thanks! in has to be in km

Answers:1 light year is around 6 trillion miles. The distance from Earth to the Moon is about 240,000 miles. Do the math. Edit: Then convert miles to km.

Question:I need the mathematical computation for how to find this.

Answers:Since light travels 300,000 km/second, or 300 million meters per second, just multiply that number by the number of seconds in 4.3 years. (60 seconds in a minute, X 60 minutes in an hour, X 24 hours in a days, X 365 days in a year, X 4.3)

Question:Determine the distance of earth to alpha centauri if the distance in light years is 4.2.

Answers:3.97342193 10 to the 22nd power meters

Question:the star proxima centauri is about 4.2 light years from earth, or about 4/3 of a parsec. what is proxima centauri's parallax angle? a, you must knoe this star's apparent magnitude before you can estimate its distance from us. b, about 4/3 of an arcsecond c, about 3/4 of an arcsecond d, about 3/4 of a degree e, about 4/3 of a degree could you ever see Mercury high in the southern sky at midnight? a, never b, occasionally c, only on the vernal and autumnal equinoxes d, only on the summer and winter solstices e, only when mercury is executing retrograde motion

Answers:Question 1: Answer B (per definition of the parsec) Question 2: Answer A because Mercury is closer to the sun than the earth and a midnight you look away from the sun

From Youtube

Sid Meier's Alpha Centauri Secret Project: The Human Genome Project :From the videogame known as Sid Meier's Alpha Centauri, this is the secret project video for The Human Genome Project. Secret project details: Cost: 200 Prerequisite Technology: Biogenetics Effect: One extra talent at every base. "To map the very stuff of life; to look into the genetic mirror and watch a million generations march past. That, friends, is both our curse and our proudest achievement. For it is in reaching to our beginnings that we begin to learn who we truly are." -- Academician Prokhor Zakharov, "Address to the Faculty" Ripped with HCl's Wing Commander Movie Player: hcl.wcrevival.de

Moon moving away from Earth? :Earth's moon was born around 4.5 billion years ago in a titanic collision between our planet and a Mars-sized sibling, according to the leading theory. The enormous impact threw debris into orbit around the young Earth and from this maelstrom the Moon coalesced. For the last few billion years the moon's gravity has been raising tides in Earth's oceans which the fast spinning Earth attempts to drag ahead of the sluggishly orbiting moon. The result is that the moon is being pushed away from Earth by 1.6 inches (4 centimeters) per year and our planet's rotation is slowing. If left unabated, the moon would continue in its retreat until it would take about 47 days to orbit the Earth. Both Earth and moon would then keep the same faces permanently turned toward one another as Earth's spin would also have slowed to one rotation every 47 days. The Moon is moving 1 inches every year away from planet Earth. When it has moved another 14600 miles we will no longer have the privilege to see a total eclipse. The Moon will be too far in space to completely eclipse the Sun. Eventually the distance between Earth and the Moon will be so great that the gravitational pull on Earth's tides will be insignificant. www.space.com